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Drug consumption and additional risk factors associated with microscopic colitis: Case-control study
Revista Espanola De Enfermedades Digestivas
|June 3, 2015
Summary
Microscopic colitis risk factors include abdominal pain, weight loss, celiac disease, and topiramate use. Older age and NSAIDs in IBS patients also increase risk.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Microscopic colitis is a frequent cause of chronic diarrhea with unknown etiology.
- Potential triggers include prescribed medications and other risk factors.
Purpose of the Study:
- To investigate the influence of drug intake and other risk factors on microscopic colitis.
- To identify key associations in patients with chronic watery diarrhea.
Main Methods:
- A prospective case-control study was conducted from 2008 to 2011.
- Adult patients with chronic watery diarrhea were recruited, and diagnoses confirmed via histopathology.
Main Results:
- Five significant risk factors for microscopic colitis were identified: abdominal pain, weight loss, celiac disease, topiramate intake, and older age at diagnosis.
- Non-steroidal anti-inflammatory drug (NSAID) use was linked to microscopic colitis in patients meeting irritable bowel syndrome (IBS) criteria.
Conclusions:
- Microscopic colitis is associated with autoimmune diseases, older age, and topiramate use.
- NSAID use is a risk factor specifically in a subgroup of IBS patients with microscopic colitis.
