Related Experiment Video
Updated: Apr 11, 2026
08:03
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
2.9K
Region Evolution eXplorer - A tool for discovering evolution trends in ontology regions
Victor Christen1, Michael Hartung2, Anika Groß2
1Department of Computer Science, Universität Leipzig, Augustusplatz 10, Leipzig, Germany.
Journal of Biomedical Semantics
|June 3, 2015
Summary
Life science ontologies evolve over time. The Region Evolution eXplorer (REX) system helps analyze these changes, identifying stable and unstable ontology regions for better application and development.
Area of Science:
- Bioinformatics
- Computational Biology
- Ontology Engineering
Background:
- Numerous life science ontologies exist for applications like gene annotation and functional analysis.
- Ontologies require adaptation due to new scientific insights, necessitating the study of their evolution.
- Understanding ontology changes aids in improving their development and application.
Purpose of the Study:
- To develop a system for exploring the evolution of specific parts (regions) within life science ontologies.
- To provide a platform for analyzing changes and trends in ontology development over time.
Main Methods:
- Development of REX (Region Evolution eXplorer), a web-based system.
- Analysis of approximately 1,000 versions from 16 prominent life science ontologies.
- Implementation of interactive workflows for explorative analysis of ontology regions.
Main Results:
- REX offers a platform to analyze the evolution of approximately 1,000 versions of 16 life science ontologies.
- Interactive workflows enable the study of changing ontology regions and long-term evolution trends.
Conclusions:
- REX is a user-friendly web application for identifying stable and unstable regions in large life science ontologies.
- The system facilitates monitoring ontology evolution for improved development and application.
- REX is accessible at http://www.izbi.de/rex.
More Related Videos
08:32Neurovascular Network Explorer 2.0: A Simple Tool for Exploring and Sharing a Database of Optogenetically-evoked Vasomotion in Mouse Cortex In Vivo
Published on: May 4, 2018
6.8K
07:09A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
10.8K
Related Concept Videos
02:54Evolutionary Relationships through Genome Comparisons
7.3K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.3K
02:35What is Evolutionary History?
45.1K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
45.1K
01:17Region of Convergence
1.1K
The z-transform is a powerful mathematical tool used in the analysis of discrete-time signals and systems. It is a crucial tool in the analysis of discrete-time systems, but its convergence is limited to specific values of the complex variable z. This range of values, known as the Region of Convergence (ROC), is fundamental in determining the behavior and stability of a system or signal. The ROC defines the region in the complex plane where the z-transform converges, which can take various...
1.1K
02:31Synteny and Evolution
4.0K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
4.0K
01:20Evolutionary Psychology
1.2K
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
1.2K
01:08Evolution of Microbial Genome
56
Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
56