Preferences for genetic testing for colorectal cancer within a population-based screening program: a discrete choice...

Area of Science:

• Genetics
• Public Health
• Cancer Research

Background:

• Colorectal cancer (CRC) screening is essential for early detection and improved survival.
• Genetic predispositions, such as Lynch syndrome, familial adenomatous polyposis (FAP), and familial colorectal cancer (FCC), significantly increase CRC risk.
• Understanding public preferences for genetic testing is vital for effective screening program implementation.

Purpose of the Study:

• To explore public preferences regarding genetic testing for colorectal cancer (CRC) in a screening context.
• To assess willingness to participate in genetic testing for Lynch syndrome, FAP, and FCC.
• To identify factors influencing preferences for genetic screening characteristics.

Main Methods:

• A Discrete Choice Experiment (DCE) was administered to 532 respondents aged 55-65 years.
• Panel latent class models were utilized to estimate preferences for screening situation and test characteristics.
• Willingness to participate in specific genetic screening initiatives was derived from estimated preferences.

Main Results:

• Preferences varied based on education and anxiety levels, influencing the perceived importance of colonoscopy frequency, CRC development probability, and survival.
• Lower-educated individuals and those with anxiety prioritized colonoscopy frequency and CRC risk over survival.
• These differing preferences led to divergent participation intentions for FCC and FAP screening.

Conclusions:

• The general population demonstrates willingness to participate in genetic screening for colorectal cancer (CRC).
• Informing individuals about genetic predisposition and the importance of follow-up colonoscopies is critical for maximizing survival.
• Tailoring communication strategies based on demographic and psychological factors may enhance engagement in genetic CRC screening programs.