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Increased Circulating Anti-inflammatory Cells in Marathon-trained Runners.

K Rehm1, I Sunesara2, G D Marshall1

  • 1Department of Medicine, University of Mississippi Medical Center, Jackson, United States.

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|June 4, 2015
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Summary
This summary is machine-generated.

Marathon runners show altered immune cell profiles, with fewer T helper 1 and regulatory cells but more anti-inflammatory cells. This immune shift may explain increased susceptibility to infections and inflammatory diseases in endurance athletes.

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Area of Science:

  • Immunology
  • Exercise Physiology
  • Endurance Sports Medicine

Background:

  • Exercise training significantly impacts immune function.
  • Marathon training is linked to increased infectious and inflammatory disease risk, but mechanisms remain unclear.

Purpose of the Study:

  • To compare circulating CD4+ T cell subsets in marathon runners versus non-marathon controls.
  • Investigate potential immune mechanisms underlying altered disease susceptibility in endurance athletes.

Main Methods:

  • Flow cytometry was used to measure CD4+ T cell subpopulations in 19 marathoners and 19 controls.
  • Key subsets analyzed included T helper 1, T helper 2, regulatory T cells, CD4+ IL10+, and CD4+ TGFβ+.

Main Results:

  • Marathon runners exhibited significantly lower T helper 1 and regulatory T cells compared to controls.
  • Marathon runners showed significantly higher T helper 2, CD4+ IL10+, and TGFβ+ cells.
  • A significantly lower T helper 1/T helper 2 ratio was observed in marathon-trained runners.

Conclusions:

  • Endurance training, like marathon running, increases anti-inflammatory immune cells.
  • This shift in immune cell populations may underlie the increased incidence of infectious and inflammatory diseases in endurance athletes.