Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand Binding Sites02:40

Ligand Binding Sites

15.9K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.9K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

6.0K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

I-SCREEN: Development of an AI-based infrastructure for community-wide screening and prediction of progression in age-related macular degeneration providing accessible shared care.

Eye (London, England)·2026
Same author

Cognitive workload affects ocular accommodation and pupillary response.

Journal of optometry·2022
Same author

The influence of proprioception on reading performance.

Clinical & experimental optometry·2016
Same author

Current concepts in myopia control.

Collegium antropologicum·2013
Same author

The importance of measuring dynamic visual acuity.

Collegium antropologicum·2013

Related Experiment Video

Updated: Apr 11, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.7K

Individually designed PALs vs. power optimized PALs adaptation comparison.

Nataša Vujko Muždalo, Matjaž Mihelčič

    Collegium Antropologicum
    |June 5, 2015
    PubMed
    Summary

    First-time wearers adapt more easily and quickly to fully individualized progressive addition lenses (PAL). Precise measurements and frame fitting significantly improve wearer comfort and visual acuity.

    Area of Science:

    • Ophthalmology
    • Optometry
    • Vision Science

    Background:

    • Growing demand for visual correction across all distances, especially for the presbyopic population.
    • Progressive addition lenses (PAL) offer a potential solution for multifocal vision correction.
    • Adaptation to PALs can be challenging for new users, with significant individual variability.

    Purpose of the Study:

    • To analyze factors influencing adaptation to progressive addition lenses (PAL) in first-time wearers.
    • To compare the adaptation process between individually fitted PALs and power-optimized PALs.
    • To understand the impact of individual parameters on wearer comfort and adaptation time.

    Main Methods:

    • Study included only novice PAL wearers to avoid prior lens design bias.

    More Related Videos

    A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
    14:34

    A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

    Published on: April 3, 2026

    160
    Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
    13:49

    Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

    Published on: December 6, 2017

    12.2K

    Related Experiment Videos

    Last Updated: Apr 11, 2026

    Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
    06:50

    Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

    Published on: January 26, 2024

    2.7K
    A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
    14:34

    A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English

    Published on: April 3, 2026

    160
    Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
    13:49

    Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

    Published on: December 6, 2017

    12.2K
  • Compared individually fitted PALs (Rodenstock Impression FreeSign) with power-optimized PALs (Rodenstock Multigressiv MyView).
  • Monitored adaptation over four weeks, collecting subjective user ratings on comfort and visual impression.

    • Main Results:

    • Individually fitted PALs demonstrated easier and quicker adaptation compared to power-optimized lenses.
    • Subjective user impressions indicated a preference for individually tailored progressive lenses.
    • Individual parameters significantly influence the adaptation process and comfort.

    Conclusions:

    • Fully individualized progressive addition lenses facilitate a smoother and faster adaptation for new users.
    • Accurate refraction, precise ocular/facial measurements, and proper frame fitting are crucial for optimal PAL performance.
    • User subjective feedback is vital for understanding progressive lens design and characteristics in optometric practice.