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Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies
1Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore. lohxj@imre.a-star.edu.sg.
Chemical Communications (Cambridge, England)
|June 5, 2015
Abstract:
A cationic star copolymer with a β-cyclodextrin core was developed for nonviral gene transfer to mouse embryonic stem cells (mESCs). The copolymer comprises poly(2-dimethyl aminoethyl methacrylate) as the cationic component and poly(2-hydroxyethyl methacrylate) as the non-toxic stealth component. These materials have very low toxicity and show highly efficient transfection to mESC colonies.
