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[Morphological characteristic dysplastic features on colonic adenomas]
T Gvamichava1, T Machavariani1, I Gachechiladze1
1I. Javakhishvili State University, A. N. Natishvili Institute of Morphology, Tbilisi, Georgia.
Georgian Medical News
|June 5, 2015
Summary
Tubular adenomas with severe dysplasia show reduced cell differentiation and increased proliferation, indicating a risk for carcinoma in situ. These changes highlight a spectrum of colonic polyp development from microadenomas to malignant transformation.
Area of Science:
- Gastroenterology
- Oncology
- Cell Biology
Context:
- Tubular adenomas with severe dysplasia represent a critical stage in colorectal polyp development.
- Understanding these morphological and functional changes is key to assessing cancer risk.
Purpose:
- To characterize the morphological and functional alterations in tubular adenomas with severe dysplasia.
- To evaluate the relationship between adenomas, microadenomas, and the risk of colorectal carcinoma in situ.
Summary:
- Severe dysplasia in tubular adenomas is marked by low cytodifferentiation, high epithelial cell proliferation (3H-Thymidine uptake), and reduced goblet cells.
- Tumor parenchyma exhibits decreased functional activity (ATP-ase), while the stroma shows increased young fibroblasts disrupting fibrillogenesis.
- Suppressed local immunity, elevated T-suppressor activity, and altered vascular morphology are observed.
- Adenomas with severe dysplasia are identified as risk factors for carcinoma in situ, with microadenomas and adenomas representing a continuum of dysplastic changes.
Impact:
- This research identifies adenomas with severe dysplasia as significant risk factors for developing carcinoma in situ.
- It proposes that colonic microadenomas are precursors to adenomas and can potentially undergo malignant transformation.
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