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Congenital CD59 Deficiency

Britta Höchsmann1, Hubert Schrezenmeier1

  • 1Institute of Transfusion Medicine, University of Ulm, Ulm, Germany; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen, University Hospital of Ulm, Helmholtzstraße 10, Ulm 89081, Germany.

Hematology/Oncology Clinics of North America
|June 5, 2015
PubMed

The severe clinical symptoms of inherited CD59 deficiency confirm the importance of CD59 as essential complement regulatory protein for protection of cells against complement attack, in particular protection of hematopoietic cells and human neuronal tissue. Targeted complement inhibition might become a treatment option as suggested by a case report. The easy diagnostic approach by flow cytometry and the advent of a new treatment option should increase the awareness of this rare differential diagnosis and lead to further studies on their pathophysiology.

Keywords:
CD59 deficiencyGlycosylphosphatidylinositol anchorHomologous restriction factorMembrane attack complex inhibitory factorMembrane inhibitor of reactive lysisParoxysmal nocturnal hemoglobinuriaTerminal complement system

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