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Human fetal iridocorneal angle: a light and scanning electron microscopic study
1Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth.
The British Journal of Ophthalmology
|November 1, 1989
Summary
Human fetal eye development reveals distinct cellular changes in the iridocorneal angle. Early gaps in corneal endothelium evolve into larger openings, facilitating anterior chamber communication.
Area of Science:
- Ophthalmology
- Developmental Biology
- Microscopy
Background:
- The iridocorneal angle and trabecular meshwork are crucial for aqueous humor outflow.
- Understanding their developmental morphology is key to identifying congenital glaucoma mechanisms.
Purpose of the Study:
- To investigate the morphological changes in the cellular lining of the human fetal anterior chamber angle recess.
- To characterize the development of the trabecular meshwork and its cellular components.
Main Methods:
- Scanning electron microscopy (SEM) was used to examine human fetal eyes.
- Tissue samples from 32 eyes (17 fetuses, 12-22 weeks gestational age) were analyzed.
Main Results:
- Hexagonal corneal endothelial cells extended near the angle apex in younger fetuses (12-14 weeks).
- Intercellular gaps (2-6 microns) were consistently observed in the endothelial lining.
- Uveal trabecular endothelial cells, distinct from corneal endothelium, lined the maturing meshwork.
- Gap frequency and size increased with development, becoming prominent by 18-20 weeks.
Conclusions:
- The developing trabecular meshwork exhibits intercellular gaps that facilitate communication.
- These findings offer insights into the 'Barkan's membrane' theory of congenital glaucoma.