Oxidized regenerated cellulose in breast surgery: experimental model

Area of Science:

• Biomaterials Science
• Surgical Oncology
• Plastic Surgery

Background:

• Breast-conserving surgery (BCS) with radiotherapy is standard for early-stage breast cancer.
• Oncoplastic procedures (OPP) improve cosmetic results in BCS but can be insufficient.
• Oxidized regenerated cellulose (ORC) may enhance OPP outcomes, but ultrastructural data is lacking.

Purpose of the Study:

• To evaluate the ultrastructural integration and tissue response of ORC as a filler in simulated BCS cavities.

Main Methods:

• A BCS defect was created in Wistar rats, with ORC implanted on one side and control on the other.
• Tissue samples were analyzed at 10, 20, and 30 weeks for volume, vascularization, fibrosis, and inflammation.

Main Results:

• ORC implantation resulted in diffuse fibrosis and homogeneous neovascularization without capsule formation or inflammation.
• Consistent volume retention was observed at 20 and 30 weeks (approximately 80%).

Conclusions:

• ORC integrates well into soft tissues, promoting fibrosis and angiogenesis while avoiding adverse reactions.
• ORC shows potential as a biomaterial to improve cosmetic results in oncoplastic breast surgery.