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Tenascin-C: Its functions as an integrin ligand

Richard P Tucker1, Ruth Chiquet-Ehrismann2

  • 1Department of Cell Biology and Human Anatomy, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA.

The International Journal of Biochemistry & Cell Biology
|June 10, 2015
PubMed

Insights

Tenascin-C interacts with specific integrins, influencing cell behavior like proliferation and differentiation. This knowledge holds potential for stem cell therapies.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Regenerative Medicine

Background:

  • Tenascin-C is a key extracellular matrix protein involved in cell adhesion and migration.
  • Integrins are cell surface receptors that mediate cell-matrix and cell-cell interactions.

Purpose of the Study:

  • To review experimental evidence on tenascin-C and integrin interactions.
  • To identify integrin binding sites on tenascin-C.
  • To understand the impact of these interactions on cell behavior.

Main Methods:

  • Literature review of experimental studies on tenascin-C/integrin interactions.
  • Analysis of identified integrin binding sites and motifs (IDG, RGD).
  • Summary of observed cellular responses to tenascin-C/integrin binding.

Main Results:

  • Four integrins (α9β1, αVβ3, α8β1, αVβ6) bind to tenascin-C's third fibronectin type III domain.
  • α9β1 recognizes an IDG motif; others recognize an RGD motif.
  • Tenascin-C interactions with integrins promote cell proliferation, inhibit apoptosis, and influence stem cell differentiation.

Conclusions:

  • Specific tenascin-C/integrin interactions modulate critical cellular functions.
  • Understanding these interactions is crucial for developing targeted therapies.
  • Potential applications exist in stem cell-based therapies, particularly for neuronal differentiation.
Keywords:
Extracellular matrixIDGIntegrinRGDTenascin

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