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Tenascin-C: Its functions as an integrin ligand
Richard P Tucker1, Ruth Chiquet-Ehrismann2
1Department of Cell Biology and Human Anatomy, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA.
The International Journal of Biochemistry & Cell Biology
|June 10, 2015
Summary
Tenascin-C interacts with specific integrins, influencing cell behavior like proliferation and differentiation. This knowledge holds potential for stem cell therapies.
Area of Science:
- Biochemistry
- Cell Biology
- Regenerative Medicine
Background:
- Tenascin-C is a key extracellular matrix protein involved in cell adhesion and migration.
- Integrins are cell surface receptors that mediate cell-matrix and cell-cell interactions.
Purpose of the Study:
- To review experimental evidence on tenascin-C and integrin interactions.
- To identify integrin binding sites on tenascin-C.
- To understand the impact of these interactions on cell behavior.
Main Methods:
- Literature review of experimental studies on tenascin-C/integrin interactions.
- Analysis of identified integrin binding sites and motifs (IDG, RGD).
- Summary of observed cellular responses to tenascin-C/integrin binding.
Main Results:
- Four integrins (α9β1, αVβ3, α8β1, αVβ6) bind to tenascin-C's third fibronectin type III domain.
- α9β1 recognizes an IDG motif; others recognize an RGD motif.
- Tenascin-C interactions with integrins promote cell proliferation, inhibit apoptosis, and influence stem cell differentiation.
Conclusions:
- Specific tenascin-C/integrin interactions modulate critical cellular functions.
- Understanding these interactions is crucial for developing targeted therapies.
- Potential applications exist in stem cell-based therapies, particularly for neuronal differentiation.
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