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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
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Tabletability Modulation Through Surface Engineering.

Frederick Osei-Yeboah1, Changquan Calvin Sun1

  • 1Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, 55455.

Journal of Pharmaceutical Sciences
|June 11, 2015
PubMed
Summary

Poor powder tabletability, a common challenge in tablet development, can be overcome. Surface coating microcrystalline cellulose beads effectively modulates tabletability by altering the outermost layer properties, offering a versatile solution.

Keywords:
compactioncompressionfluid-bedhardnessmaterials sciencepolymerspolyvinylpyrrolidonepowder technologytablet

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Poor powder tabletability is a significant hurdle in developing high-quality tablets.
  • Achieving desired tablet properties often requires overcoming material limitations.

Purpose of the Study:

  • To investigate surface coating as a strategy to enhance powder tabletability.
  • To demonstrate the versatility of surface coating for controlling tablet properties.

Main Methods:

  • Utilizing noncompressible microcrystalline cellulose beads as a model system.
  • Applying various surface coating materials to the beads.
  • Evaluating the impact of coating on tabletability.

Main Results:

  • Surface coating was demonstrated as an effective method for modulating tabletability.
  • The tabletability of coated particles was primarily determined by the properties of the coating material.
  • This strategy showed broad applicability irrespective of the core material.

Conclusions:

  • Surface coating offers a tunable approach to overcome poor powder tabletability.
  • The outermost layer's properties dictate particle tabletability, making surface modification a powerful tool.
  • This technique presents a widely applicable solution for tablet formulation challenges.