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Updated: Apr 10, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
[Whipple's disease manifested as difficult-to-diagnose polyarthralgia: a case report and literature review]
Guilherme Almeida Rosa da Silva1, José Soares Pires Neto1
1Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, RJ, Brasil.
Abstract:
Whipple's disease is a rare and multisystemic bacterial disease caused by the Gram-positive bacillus Tropheryma whipplei. Since it is a rare disease with a varied clinical presentation, its diagnosis is often delayed. The joint manifestations may precede the typical syndrome in decades, being a challenge for specialists and internists. We report a case of Whipple's disease in a man with polyarthralgia whose diagnosis was established after extensive clinical deterioration over five years.
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