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The non-human primate experimental glaucoma model.

Claude F Burgoyne1

  • 1Devers Eye Institute, Optic Nerve Head Research Laboratory, Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, OR, United States.

Experimental Eye Research
|June 14, 2015
PubMed
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The non-human primate (NHP) experimental glaucoma (EG) model offers unique insights into early glaucomatous damage by mimicking human optic nerve head anatomy. However, its limitations include high costs, rare spontaneous disease, and genetic manipulation challenges.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Animal Models

Background:

  • The non-human primate (NHP) experimental glaucoma (EG) model is crucial for studying human glaucoma.
  • NHP optic nerve head (ONH) anatomy closely resembles human ONH.
  • This model allows systematic study of early visual system responses to elevated intraocular pressure (IOP).

Purpose of the Study:

  • To summarize the strengths and weaknesses of the NHP EG model.
  • To review the history, methods, findings, and future directions of NHP EG research.
  • To guide researchers in utilizing NHP EG and non-NHP EG models for clinically relevant knowledge.

Main Methods:

  • Review of existing literature on NHP EG models.
  • Analysis of NHP EG model's utility in studying glaucomatous damage progression.
Keywords:
Experimental glaucomaGlaucomaMonkeyNon-human primateOptic nerveOptic nerve headRemodelingRetinaSclera

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  • Comparison with alternative optic neuropathy models.

    • Main Results:

    • NHP EG model excels in studying early visual system responses to chronic IOP elevation.
    • NHPs are impractical for large-scale studies and rarely exhibit spontaneous glaucoma.
    • Genetic manipulation in NHPs is limited, primarily relying on viral vectors.

    Conclusions:

    • The NHP EG model provides valuable insights into glaucoma pathogenesis, particularly early changes.
    • Limitations necessitate consideration of alternative models for specific research questions.
    • Future research should focus on overcoming current NHP EG model constraints for broader applicability.