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Risk factor differences between type 2 diabetes patients with ischemic cerebrovascular versus coronary heart diseases
Ying Yang1, Biao Huang2, Shuangquan Tan2
1Department of Neurology, The First People's Hospital of Yunnan Province, Kunming 510032, China.
Insights
Type 2 diabetes patients with heart conditions show distinct risk factors. Higher blood pressure and HbA1c levels in type 2 diabetes mellitus patients may signal ischemic cerebrovascular disease over coronary heart disease.
Area of Science:
- Cardiology
- Endocrinology
- Neurology
Background:
- Type 2 diabetes mellitus (T2DM) shares risk factors with ischemic cerebrovascular diseases (ICVD) and coronary heart diseases (CHD).
- Limited research directly compares risk factor differences between T2DM patients with ICVD and CHD upon hospital admission.
Purpose of the Study:
- To compare common risk factors at admission between T2DM patients with ICVD and those with CHD.
- To identify distinct risk profiles associated with ICVD and CHD in T2DM patients.
Main Methods:
- A cross-sectional study involving 1208 T2DM patients over three years.
- Retrospective data collection and multivariate logistic regression analyses were used for comparison.
Main Results:
- ICVD and CHD patients had higher systolic blood pressure (SBP), older age, and lower HDL cholesterol compared to T2DM patients without these conditions.
- Reduced estimated glomerular filtration rate was linked to CHD (p<0.05).
- T2DM patients with ICVD showed higher SBP and HbA1c levels than those with CHD.
Conclusions:
- Significant differences exist in common risk factors at admission for T2DM patients with ICVD versus CHD.
- Elevated SBP and HbA1c levels may serve as indicators for ICVD in T2DM patients.
Aims:
Type 2 diabetes mellitus (T2DM) is a major risk factor, and shares many common risk factors with ischemic cerebrovascular diseases (ICVD) and coronary heart diseases (CHD). Few studies have directly compared the differences in common risk factors between T2DM patients with ICVD and CHD at admission.
Methods:
In this cross-sectional study, T2DM patients with or without first-ever ICVD or CHD admitted to our hospital over 3 years were enrolled. Patients' data were retrospectively collected and compared using multivariate logistic regression analyses.
Results:
In total, 1208 T2DM patients were enrolled (57.5% men). The median age was 59 years (interquartile range [IQR] 51-69), and duration of diabetes was 7 years (IQR 3-10). Two hundred and two patients (16.7%) were diagnosed with ICVD, 345 (28.6%) with CHD, and 661 (54.7%) had neither ICVD nor CHD. Compared with T2DM patients without ICVD or CHD, ICVD and CHD patients had higher systolic blood pressure (SBP) and older age but lower high-density lipoprotein cholesterol levels (all p<0.01), whereas reduced estimated glomerular filtration rate was only associated with CHD (p<0.05). Furthermore, ICVD patients had higher SBP (every 10-mmHg increase, OR=1.38, 95% CI: 1.26-1.51) and HbA1c levels (OR=1.18, 95% CI: 1.06-1.31) than CHD patients.
Conclusions:
T2DM patients with ICVD and CHD have differences in common risk factors at admission. Higher systolic blood pressure and HbA1c levels may indicate ICVD.
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