Related Experiment Video
Updated: Apr 10, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
Continuous Administration of Vancomycin through a Long Intestinal Tube for Clostridium difficile Infection
Naoto Mizumura1, Koichi Demura, Masayasu Kawasaki
1Department of Surgery, Bellland General Hospital, Japan.
Abstract:
A 76-year-old previously healthy Japanese man experienced severe diarrhea (8,000 mL per day) after undergoing laparotomy for small bowel obstruction and was diagnosed with Clostridium difficile infection. Although he developed a maculopapular rash secondary to the systemic absorption of enteral vancomycin (VCM), the patient was successfully treated with the continuous administration of VCM through a long intestinal tube placed in the terminal ileum. This method ensured the reliable delivery of VCM to the colon, while the continuous administration maintained high fecal levels of the drug. This treatment approach is an effective minimally invasive option for patients with severe diarrhea.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Dosage Interval and Administration Route: Determination Methods
Drugs for Treatment of Ulcerative Colitis in IBD
Urinary Tract Infection IV: Nursing Management

