Related Experiment Video
Updated: Apr 10, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
[Management of stable chronic coronary artery disease]
1Medizinische Klinik 2, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland, stephan.achenbach@uk-erlangen.de.
Insights
Stable coronary artery disease diagnosis involves clinical assessment, noninvasive testing for intermediate risk, and invasive angiography for high-risk patients. Lifelong medication is crucial post-revascularization, with annual ischemia testing not mandated by guidelines.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Interventional Cardiology
Context:
- Stable coronary artery disease (CAD) is a prevalent cardiovascular condition.
- Diagnosis relies on a stepwise approach, starting with clinical evaluation, ECG, and echocardiography.
- Risk stratification guides further diagnostic and therapeutic decisions.
Purpose:
- To outline the diagnostic algorithm for stable coronary artery disease.
- To detail the recommended noninvasive and invasive testing strategies.
- To provide guidance on medical therapy and revascularization decisions.
Summary:
- Initial assessment identifies low-risk patients (<15% probability) who require no further work-up.
- Intermediate-risk patients (15-85% probability) benefit from noninvasive ischemia testing or coronary CT angiography.
- High-risk patients or those symptomatic despite medical therapy are referred for invasive angiography and potential revascularization.
Impact:
- Optimizes diagnostic pathways, reducing unnecessary invasive procedures.
- Emphasizes personalized treatment strategies based on patient characteristics and risk.
- Clarifies the role of revascularization and lifelong medical management post-intervention.
Abstract:
Stable coronary artery disease is one of the most frequent conditions encountered in cardiology. The diagnostic algorithm encompasses several steps, the first of which is a clinical assessment with an electrocardiogram (ECG) and echocardiography to determine the probability of disease. No further work-up is recommended if the probability of coronary artery disease remains below 15 %. For patients with an intermediate probability between 15 % and 85 %, noninvasive diagnostic testing for ischemia and coronary computed tomography (CT) angiography are recommended. In the case of a positive result, medicinal therapy should be started in order to lower the event risk and alleviate symptoms. Patients with large areas of inducible ischemia and patients who remain symptomatic in spite of medicinal therapy should undergo invasive angiography. Revascularization options include bypass surgery and, more liberally than previously, percutaneous coronary intervention with stent placement and must be decided on the basis of patient characteristics. Consultation in the form of a "heart team" is recommended. After revascularization, medicinal therapy must be continued on a lifelong basis. The widely practiced routine of annual ischemia testing in patients with known coronary artery disease is not enforced by current guidelines.
More Related Videos
09:12Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
Related Concept Videos
Angina IV: Management
Atherosclerosis III: Management
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Coronary Artery Disease IV: Preventive Measures
Angina V: Nursing Management