Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.6K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Bone Disorders01:29

Bone Disorders

8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

14.8K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.8K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

12.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
12.1K
Tissue Transplantation01:24

Tissue Transplantation

1.3K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality Improvement Intervention for Reduction of Redundant Testing.

Academic pathology·2017
Same author

Hematologic Disorders: Anemia.

FP essentials·2015
Same author

Hematologic Disorders: Blood Transfusion Products.

FP essentials·2015
Same author

Hematologic Disorders: Sickle Cell Disease.

FP essentials·2015
Same author

Chondrosarcoma of the tongue: a case report and a review of the literature.

The Laryngoscope·2012
Same author

Disseminated Cryptococcus with ocular cryptococcoma in a human immunodeficiency virus-negative patient.

International ophthalmology·2012
Same journal

Skin Cancer: Management of Cutaneous Melanoma.

FP essentials·2026
Same journal

Skin Cancer: Management of Actinic Keratoses and Keratinocyte Carcinomas.

FP essentials·2026
Same journal

Skin Cancer: Diagnosis.

FP essentials·2026
Same journal

Skin Cancer: Screening and Prevention.

FP essentials·2026
Same journal

Skin Cancer.

FP essentials·2026
Same journal

Obesity Management: Surgical Interventions.

FP essentials·2026
See all related articles

Related Experiment Video

Updated: Apr 10, 2026

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

4.8K

Hematologic Disorders: Bone Marrow Failure.

David Baltierra1, Tiffany Harper1, Matthew Page Jones1

  • 1West Virginia University School of Medicine Robert C. Byrd Health Sciences Center-Eastern Division, 2500 Foundation Way, Martinsburg, WV 25401.

FP Essentials
|June 17, 2015
PubMed
Summary
This summary is machine-generated.

Idiopathic aplastic anemia (AA) causes pancytopenia and hypocellular bone marrow. Treatment involves immunosuppression or bone marrow transplant, with survival rates improving significantly.

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.7K

Related Experiment Videos

Last Updated: Apr 10, 2026

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

4.8K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
08:00

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

14.7K

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Pancytopenia with hypocellular bone marrow is often idiopathic aplastic anemia (AA), but other causes include inherited syndromes, drugs, infections, and rheumatologic diseases.
  • AA can be stable or progress to myelodysplastic syndrome, acute leukemia, or paroxysmal nocturnal hemoglobinuria.
  • Supportive care and specific therapies are crucial for managing AA and its complications.

Purpose of the Study:

  • To review the causes, complications, and current management strategies for aplastic anemia.
  • To highlight the efficacy of different treatment modalities, including immunosuppression and bone marrow transplantation.
  • To discuss the prognosis and survival rates associated with aplastic anemia treatment.

Main Methods:

  • Review of current literature on aplastic anemia diagnosis and treatment.
  • Analysis of therapeutic outcomes for various treatment regimens.
  • Discussion of supportive care measures and emerging transplantation techniques.

Main Results:

  • Corticosteroids and erythropoietin are ineffective for AA; G-CSF is reserved for severe infections.
  • Supportive care with leukocyte-poor RBC transfusions minimizes alloimmunization.
  • Horse/rabbit antithymocyte globulin plus cyclosporine is first-line for many AA patients, yielding 75-85% 5-year survival.
  • HLA-matched sibling bone marrow transplant is ideal for younger patients, but matched unrelated donors are increasingly used.

Conclusions:

  • Aplastic anemia requires tailored treatment based on disease severity and patient factors.
  • Immunosuppressive therapy with ATG and cyclosporine offers good survival rates.
  • Hematopoietic stem cell transplantation remains the curative option for eligible patients, with expanding donor sources.