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Published on: August 6, 2019
Actinobenzoquinoline and Actinophenanthrolines A-C, Unprecedented Alkaloids from a Marine Actinobacterium
Sang-Jip Nam1, Christopher A Kauffman1, Paul R Jensen1
1†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, and ‡Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0204, United States.
Abstract:
Chemical investigation of a marine actinomycete within the family Streptomycetaceae (our strain CNQ-149) has led to the isolation of the unprecedented alkaloids, actinobenzoquinoline (1) and actinophenanthrolines A-C (2-4). The chemical structures of 1-4 were assigned by interpretation of NMR spectroscopic data, and their absolute configurations were assigned by X-ray analysis. Actinobenzoquinoline possesses a 5-methyloxazolidin-4-one moiety and a dihydrobenzo[h]quinoline core structure, while actinophenanthrolines A-C are composed of hydroxypropanamide-substituted 1,7-phenanthroline core skeletons.
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