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Recent studies on nucleoside H-phosphonothioate and nucleoside methylphosphonothioate synthesis
J Stawiński1, T Szabó, M Thelin
1Department of Organic Chemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Nucleic Acids Symposium Series
|January 1, 1989
Abstract:
The reaction of suitably protected nucleosides with phosphinic acid in the presence of condensing agents has been investigated and applied for the preparation of nucleoside 3'-H-phosphonothioates. Studies on synthesis and separation of diastereoisomers of nucleoside 3'-methylphosphonothioates are also discussed.