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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis

T E Kononova1, O I Urazova, V V Novitskii

  • 1Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia, kononova.te@gmail.com.

Bulletin of Experimental Biology and Medicine
|June 20, 2015
PubMed

In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4(+)CD25(+)FoxP3(+) Treg lymphocytes with immunosuppressive activity.

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