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Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

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Related Experiment Video

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An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival
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Healing the NIH-Funded Biomedical Research Enterprise.

Ronald N Germain1

  • 1Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|June 20, 2015
PubMed
Summary

The current biomedical research grant system needs reform. A "person-not-project" funding model could foster creativity in new investigators and improve support for established researchers.

Area of Science:

  • Biomedical Research Funding
  • Grant Systems Analysis
  • Scientific Career Development

Background:

  • Concerns exist regarding the current biomedical research grant system in the U.S.
  • The existing R01 grant system may discourage young investigators.
  • Established researchers may also face inadequate support under the current system.

Purpose of the Study:

  • To propose an alternative funding model for biomedical research.
  • To address perceived shortcomings in the current R01 grant system.
  • To enhance support for both early-career and established investigators.

Main Methods:

  • Conceptual analysis of the R01 grant system.
  • Argumentation for a "person-not-project" funding approach.

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  • Discussion of potential benefits for research creativity and funding allocation.

    • Main Results:

    • The current system may hinder entry and progress for investigators.
    • A "person-not-project" scheme offers potential improvements.
    • This model could foster unfettered research and better align funding with investigator numbers.

    Conclusions:

    • The R01 grant system requires significant re-evaluation.
    • A "person-not-project" approach presents a viable alternative.
    • Implementing such a scheme could revitalize biomedical research support and productivity.