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Updated: Apr 9, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties
Patrick Neuberg1,2, Aurélia Perino1, Emmanuelle Morin-Picardat1,2
1Laboratory of Functional Chemo Systems, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. alwag@unistra.fr.
Abstract:
A series of polydiacetylene (PDA) - based micelles were prepared from diacetylenic surfactant bearing polyethylene glycol, by increasing UV-irradiation times. These polymeric lipid micelles were analyzed by physicochemical methods, electron microscopy and NMR analysis. Cellular delivery of fluorescent dye suggests that adjusting the polymerization state is vital to reach the full in vitro potential of PDA-based delivery systems.
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