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3D silicon neural probe with integrated optical fibers for optogenetic modulation
Eric G R Kim1, Hongen Tu, Hao Luo
1The Biomedical Engineering Department of Wayne State University, Detroit, MI 48202, USA. yxu@eng.wayne.edu.
Lab on a Chip
|June 23, 2015
Summary
This study introduces a novel 3D neural probe integrating optical fibers for optogenetics and neural recording. The device enables simultaneous optical modulation and high-resolution 3D neural signal acquisition in vivo.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optics
Background:
- Optogenetics offers powerful neural modulation for biomedical research.
- High-resolution neural recording is crucial for understanding neural circuits.
- Integrating optical and electrical recording technologies is highly desirable.
Purpose of the Study:
- To develop a novel 3D neural probe that integrates optical fibers for optogenetics.
- To enable simultaneous optical modulation and 3D neural signal recording.
- To create a robust and precisely controllable device for neural studies.
Main Methods:
- Development of a 3D neural probe utilizing a hollow parylene tube structure.
- Integration of optical fibers within the probe shanks with controlled tip positioning.
- Simultaneous in vivo recording and optogenetic modulation in rat models.
Main Results:
- Successful development of a novel 3D neural probe with integrated optical fibers.
- Demonstrated precise control over optical fiber tip placement relative to electrodes.
- Preliminary in vivo studies confirmed simultaneous optogenetic modulation and 3D neural recording.
Conclusions:
- The developed 3D neural probe effectively integrates optogenetics with high-resolution neural recording.
- This technology advances the capability for functional studies of neural tissue.
- The device shows promise for future biomedical research applications.
