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The US now has a network for comparative effectiveness research (CER) using electronic health records (EHRs) for pediatric drug studies. This new platform, CER(2), aims to improve child health research and outcomes.

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Area of Science:

  • Pediatric Health Research
  • Health Informatics
  • Comparative Effectiveness Research

Background:

  • The United States lacks a robust system for utilizing routinely collected electronic health record (EHR) data for comparative effectiveness research (CER) in pediatric drug therapeutics and child health.
  • Existing EHR data is fragmented, limiting its application in large-scale pediatric research.

Purpose of the Study:

  • To describe the creation and structure of a novel network of EHR networks designed to facilitate CER in pediatric populations.
  • To establish a platform for advancing the methodology of pediatric pharmacoepidemiology and improving child health outcomes through collaborative research.

Main Methods:

  • The American Academy of Pediatrics' Pediatric Research in Office Settings (PROS) initiated the development of the Comparative Effectiveness Research Through Collaborative Electronic Reporting (CER(2)) network.
  • CER(2) links data from PROS's ePROS network with independent practices and health systems across the US.
  • Initial proof-of-concept studies focused on psychotropic and asthma medication use and side effects, with a planned prospective study on pediatric hypertension treatment.

Main Results:

  • The CER(2) network has been established, linking multiple EHR data sources for pediatric research.
  • Initial retrospective studies have demonstrated the feasibility of using the network for CER on pediatric medications.
  • A platform is being developed to support future large-scale prospective CER studies in child health.

Conclusions:

  • The CER(2) network provides a vital resource for conducting comparative effectiveness research in pediatric drug therapeutics and other child health topics.
  • This collaborative network aims to engage researchers nationwide, advancing the methodology and application of pediatric pharmacoepidemiology.
  • The initiative holds significant potential to improve child health and healthcare through data-driven research.