[The hypothalamo-hypophyseal neurosecretory system in rats with hereditary arterial hypertension]

Histochemical and cytometrical analysis of the peptidergic Gomori-positive or hypothalamo-hypophyseal neurosecretory system (HHNS) was made in the 3 strains of rats: spontaneously hypertensive rats (SHR), rats with inherited stress-induced arterial hypertension (ISIAH), and normotensive Wistar rats. A significant increase in the production of the peptide neurohormones by the supraoptic nuclei was found in two hypertensive strains (SHR and ISIAH) compared to the normotensive Wistar rats. For ISIAH-rats, the excretion of neurohormones was more pronounced in the region of median eminence, and for SHR--in the posterior hypophyseal lobe. It was concluded that hyperfunction of HHNS can play an important role in the hypertension development in two strains or rats studied.