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Updated: Apr 8, 2026
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
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Tolerance signatures in transplant recipients
Kenneth A Newell1, Laurence A Turka
1aDepartment of Surgery, Emory University, Atlanta, Georgia bDepartment of Surgery and Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Current Opinion in Organ Transplantation
|June 25, 2015
Summary
Identifying biomarkers for transplanted organ tolerance is crucial. Distinct biomarkers exist for kidney and liver transplants, with potential for iron homeostasis markers in liver tolerance.
Area of Science:
- Transplantation immunology
- Biomarker discovery
- Immunosuppression
Background:
- Transplant tolerance allows reduced immunosuppression, minimizing drug toxicity.
- Identifying tolerance biomarkers is key for safer transplant management and understanding tolerance mechanisms.
Purpose of the Study:
- To review biomarkers that predict or identify organ transplant tolerance.
- To highlight the potential benefits of tolerance biomarker identification.
Main Methods:
- Review of studies on biomarkers in kidney and liver transplant recipients.
- Analysis of associations with immune cells (B cells, NK cells, γδ T cells) and other factors (iron homeostasis).
Main Results:
- Kidney transplant tolerance is associated with specific B cell populations.
- Liver transplant tolerance biomarkers differ, involving natural killer/γδ T cells and iron homeostasis.
- Intra-graft biomarkers may be more accurate than blood-based markers.
Conclusions:
- Progress in identifying tolerance biomarkers is promising.
- Validation in larger prospective studies is essential for immunosuppression minimization/withdrawal.
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