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Validation of circulating BNP level >1000 pg/ml in all-cause mortality: A retrospective study
Daisuke Sakamoto1, Shigeru Sakamoto2, Tsugiyasu Kanda3
1Department of Community Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Aim:
To determine the primary diseases and prognoses of patients with highly elevated levels of B-type natriuretic peptide (BNP; >1000 pg/ml), with or without heart failure.
Methods:
Medical records and echocardiograms of patients with BNP levels that fell within one of three predetermined categories (>1000 pg/ml, 200-1000 pg/ml and <200 pg/ml) were retrospectively reviewed.
Results:
There were no significant between-group differences in duration of hospitalization. Patients with BNP levels >1000 pg/ml (n = 103) or 200-1000 pg/ml (n = 100) had significantly worse 3-year survival than those with BNP levels <200 pg/ml (n = 100). The majority of patients (64/103) in the BNP >1000 pg/ml group had heart failure. The main cause of death in patients with other causes of BNP levels >1000 pg/ml (39/103) was community acquired pneumonia.
Conclusion:
A BNP level >1000 pg/ml has clinical importance in primary care medicine and hospital settings.
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