[Ultrastructural characteristics and succinate dehydrogenase activity of the hepatocyte mitochondria in cholestasis]

Ultrastructure and activity of CDG mitochondria hepatocytes were investigated in 40 patients and 20 rats with extrahepatic cholestasis. In the early period of cholestasis changing hepatocytes mitochondria takes stereotypic character. Prolonged cholestasis, adducting to accumulation of components of bile in patients was accompanied by destructive changes and decreasing activity of CDG in mitochondria. In animals a decreased activity of CDG was detected on 10th day.