[Morphogenesis of intralobular liver fibrosis in obstructive jaundice patients]

The results of ultrastructural study of the intralobular liver fibrosis in 38 patients with obstructive jaundice of various duration are presented. It is established that the appearance of fibroblast-like sinusoid cells plays a leading role in the development of intralobular liver fibrosis. The morphologic characteristics of poorly differentiated and differentiated cells of this type and their involvement in collagen fiber synthesis within liver lobules are given. It is shown that in obstructive jaundice a significant disturbance of the sinusoidal wall takes place due to the formation of collagen fibers, basal membrane that results in the worsening of the exchange between the blood and hepatocytes.