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Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
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Attention: the claustrum.

Yael Goll1, Gal Atlan2, Ami Citri3

  • 1Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University, Jerusalem, Israel.

Trends in Neurosciences
|June 29, 2015
PubMed
Summary
This summary is machine-generated.

The claustrum, a neural structure, may play a key role in attention segregation. Recent research highlights its connections and potential function in consciousness and selective attention.

Keywords:
attentionbottom upclaustrumcortexsensory modalitiestop down

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The claustrum is a poorly understood neural network situated between the insular cortex and striatum.
  • It exhibits extensive reciprocal connections with diverse cortical regions and receives subcortical neuromodulatory input.
  • A prior hypothesis proposed the claustrum as the 'seat of consciousness', reigniting research interest.

Purpose of the Study:

  • To review current literature on the claustrum, incorporating recent findings.
  • To propose a detailed hypothesis on the claustrum's function in attention segregation.

Main Methods:

  • Literature review of claustrum research.
  • Synthesis of existing data to formulate a novel hypothesis.

Main Results:

  • The claustrum's widespread cortical connectivity supports a role in integrating information.
  • Neuromodulatory inputs suggest a role in regulating neural processing.
  • Recent discoveries provide a foundation for understanding its function.

Conclusions:

  • The claustrum's unique connectivity and inputs suggest a critical role in cognitive functions.
  • A novel hypothesis posits the claustrum's involvement in the segregation of attention.
  • Further research is warranted to elucidate the claustrum's precise mechanisms in attention and consciousness.