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Updated: Apr 8, 2026

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
Published on: June 30, 2016
Attention: the claustrum
Yael Goll1, Gal Atlan2, Ami Citri3
1Department of Biological Chemistry, Institute of Life Sciences, Faculty of Natural Sciences, The Hebrew University, Jerusalem, Israel.
Abstract:
The claustrum is a mysterious thin sheet of neurons lying between the insular cortex and the striatum. It is reciprocally connected with almost all cortical areas, including motor, somatosensory, visual, auditory, limbic, associative, and prefrontal cortices. In addition, it receives neuromodulatory input from subcortical structures. A decade ago, Sir Francis Crick and Christof Koch published an influential review proposing the claustrum as the 'seat of consciousness', spurring a revival of interest in the claustrum. We review the literature on the claustrum, emphasizing recent discoveries, and develop a detailed hypothesis describing a role for the claustrum in the segregation of attention.
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