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Updated: Apr 8, 2026
06:32
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
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Refractory hypocalcaemia complicating metastatic prostatic carcinoma.
Christopher Rizzo1, Sandro Vella1, Mario J Cachia1
1Diabetes and Endocrine Centre, Mater Dei Hospital, Msida, Malta Department of Medicine, University of Malta Medical School, Msida, Malta.
BMJ Case Reports
|July 1, 2015
Summary
A 72-year-old man presented with dyspnea and lethargy, found to have pneumonia, severe hypocalcemia, and vitamin D deficiency. Bone scans revealed widespread osteoblastic metastases, indicating advanced prostate cancer with metabolic complications.
Area of Science:
- Oncology
- Endocrinology
- Cardiology
Background:
- Ischaemic heart disease
- Severe hypocalcaemia
- Vitamin D deficiency
Observation:
- Right-sided lobar pneumonia
- Prolonged corrected QT interval on ECG
- Relative hypoparathyroidism
- Markedly elevated prostate-specific antigen
Findings:
- Widespread osteoblastic bone metastases on bone scintigraphy
- Persistent severe hypocalcaemia despite treatment
Implications:
- Highlights the complex interplay between advanced prostate cancer, bone metastases, and severe metabolic disturbances.
- Underscores the importance of thorough metabolic workup in patients with malignancy and cardiorespiratory symptoms.
- Suggests potential challenges in managing severe hypocalcaemia in the context of widespread bone disease.
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