Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Psychosurgery01:30

Psychosurgery

2.3K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
2.3K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

2.1K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
2.1K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.3K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Point-of-Care Ultrasound M-Mode Analysis Using M.mode.ify: An External Validation Study for E-point Septal Separation Measurement.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine·2026
Same author

Evaluating robotic surgery skills decay and maintenance of proficiency in a high-fidelity simulated environment.

Surgical endoscopy·2026
Same author

Finding the balance between respecting autonomy and life-saving anorexia nervosa care: an Australian perspective.

Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law·2026
Same author

Recent increase in equine influenza outbreaks in the UK.

The Veterinary record·2026
Same author

Milk Fasting Times and Aspiration in Infants.

Paediatric anaesthesia·2026
Same author

What happened after the epidemic? Equine influenza surveillance sheds light on sources and seasonal risk in the United Kingdom.

Equine veterinary journal·2026
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: Apr 8, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

3.1K

Surgery for epilepsy.

Siobhan West1, Sarah J Nolan, Jennifer Cotton

  • 1Department of Paediatric Neurology, Royal Manchester Children's Hospital, Hathersage Road, Manchester, UK, M13 0JH.

The Cochrane Database of Systematic Reviews
|July 2, 2015
PubMed
Summary
This summary is machine-generated.

Epilepsy surgery can offer a cure for focal epilepsies, with 65% of patients achieving good outcomes. However, limited high-quality evidence exists, necessitating future research with prospective designs and robust statistical modeling for better patient selection and outcome prediction.

More Related Videos

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

21.4K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

18.6K

Related Experiment Videos

Last Updated: Apr 8, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

3.1K
Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

21.4K
Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy SEEG With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

18.6K

Area of Science:

  • Neurology
  • Neurosurgery
  • Evidence-based Medicine

Background:

  • Focal epilepsies affect a significant portion of individuals, with 20-70% not achieving seizure freedom with medication alone.
  • Surgical resection of the epileptogenic zone offers a potential cure and improved quality of life for eligible patients.

Purpose of the Study:

  • To assess the overall outcome of epilepsy surgery using evidence from randomized controlled trials (RCTs).
  • To evaluate outcomes based on non-randomized evidence and identify prognostic factors for postoperative seizure remission.

Main Methods:

  • Systematic search of multiple databases (Cochrane, MEDLINE, ClinicalTrials.gov) for relevant trials up to July 2013.
  • Inclusion of RCTs, cohort studies, and case series with at least 30 participants, well-defined populations, and at least one year of follow-up.
  • Independent screening, quality assessment (EPHPP, QUIPS tools), and data extraction by review authors.

Main Results:

  • 177 studies (16,253 participants) were included; only four were RCTs, with unclear or high risk of bias.
  • 65% of all participants (10,518/16,253) achieved a good surgical outcome, with significant variability across studies (13.5% to 92.5%).
  • Factors associated with better outcomes included abnormal pre-operative MRI, complete resection, mesial temporal sclerosis, and tumor presence. Data on adverse events were poor.

Conclusions:

  • Limited evidence from current studies hinders patient selection and outcome prediction for epilepsy surgery due to design issues and incomplete reporting.
  • Future research should prioritize high-quality, prospective, and adequately powered studies focusing on diagnostic tools, surgical approaches, and resection extent.
  • Standardized reporting of prognostic factors using multivariable regression and inclusion of pre/postoperative functional assessments are crucial for advancing epilepsy surgery.