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Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia

A Eghbali1, H Taherahmadi2, B Bagheri3

  • 1Pediatric Hematologist & Oncologist, Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.

Iranian Journal of Pediatric Hematology and Oncology
|July 2, 2015
PubMed

Insights

Serum ferritin levels significantly correlate with echocardiography parameters in major thalassemia patients. Regular echocardiography is recommended for assessing cardiac function and preventing mortality.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Myocardial siderosis prevention is crucial for reducing mortality in thalassemia patients.
  • Understanding the relationship between iron overload markers and cardiac function is vital.

Purpose of the Study:

  • To investigate the association between echocardiography parameters and serum ferritin levels in major thalassemia patients.

Main Methods:

  • Sixty-six major thalassemia patients were enrolled.
  • Serum ferritin levels were measured using ELISA.
  • Echocardiography assessed Ejection Fraction (EF), Fractional Shortening (FS), and E/A ratio.

Main Results:

  • Significant correlations were found between serum ferritin levels and EF (r=0.3, P=0.05).
  • A significant correlation was also observed between serum ferritin levels and FS.
  • The study included 52% females and 48% males, with a mean age of 16 ± 9 years.

Conclusions:

  • The significant association between serum ferritin levels and echocardiography parameters highlights the importance of cardiac monitoring.
  • Echocardiography is beneficial for evaluating cardiac function in major thalassemia patients.
Abstract

Keywords:
Diastolic DysfunctionEchocardiographyEjection FractionFerritinThalassemia

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