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Updated: Apr 7, 2026

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
Published on: February 21, 2025
Putting the Squeeze on Airway Epithelia
Jin-Ah Park1, Jeffrey J Fredberg1, Jeffrey M Drazen2
1Harvard T. H. Chan School of Public Health, Boston, Massachussetts.
Abstract:
Asthma is characterized by chronic inflammation, airway hyperresponsiveness, and progressive airway remodeling. The airway epithelium is known to play a critical role in the initiation and perpetuation of these processes. Here, we review how excessive epithelial stress generated by bronchoconstriction is sufficient to induce airway remodeling, even in the absence of inflammatory cells.
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