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Updated: May 22, 2025

Preparation and Structural Evaluation of Epithelial Cell Monolayers in a Physiologically Sized Microfluidic Culture Device
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Epithelial Layer Fluidization by Curvature-Induced Unjamming.

Margherita De Marzio1,2, Amit Das3, Jeffrey J Fredberg2

  • 1Brigham and Women's Hospital, Channing Division of Network Medicine, and Harvard Medical School, Boston, Massachusetts 02115, USA.

Physical Review Letters
|April 18, 2025
PubMed
Summary
This summary is machine-generated.

Surface curvature drives the epithelial unjamming transition (UJT), crucial for wound healing and development. Higher curvature enhances cell migration and tissue fluidity, while smaller tissues are more dynamic.

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Area of Science:

  • Biophysics
  • Developmental Biology
  • Cell Biology

Background:

  • Epithelial layers transition from quiescent to migratory states for tissue repair and development.
  • The unjamming transition (UJT) governs epithelial fluidization and collective cell migration.
  • Existing models often overlook the impact of surface curvature on the UJT in vivo.

Purpose of the Study:

  • Investigate the influence of surface curvature on tissue plasticity and cellular migration.
  • Explore how geometric constraints affect the unjamming transition in epithelial tissues.

Main Methods:

  • Utilized a vertex model simulating epithelial dynamics on a spherical surface.
  • Analyzed the effects of varying surface curvature on cellular rearrangements and migration.

Main Results:

  • Increased surface curvature significantly promotes the unjamming transition.
  • Higher curvature reduces energy barriers for cell rearrangements, enhancing intercalation and mobility.
  • Epithelial structures become more malleable and migratory with increasing curvature (smaller size) and more rigid with decreasing curvature (larger size).

Conclusions:

  • Surface curvature is a critical factor modulating epithelial tissue plasticity and collective cell migration.
  • Findings offer a framework for understanding the interplay between cell behavior, tissue geometry, and remodeling during development and regeneration.