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Published on: March 19, 2015
Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008
I-Ching Sam1, Yvonne C F Su2, Yoke Fun Chan3
1Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg.
Abstract:
Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associated with increased incidence of influenza B. We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years.
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