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Related Experiment Video

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Quantitative single-mode fiber based PS-OCT with single input polarization state using Mueller matrix.

Zhenyang Ding1, Chia-Pin Liang2, Qinggong Tang3

  • 1College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China ; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 USA ; These authors contributed equally to this work.

Biomedical Optics Express
|July 3, 2015
PubMed
Summary
This summary is machine-generated.

We developed a simple single-mode fiber polarization-sensitive optical coherence tomography (PS-OCT) method to measure tissue birefringence. This technique accurately quantifies phase retardance and optic axis orientation in biological tissues.

Keywords:
(170.0110) Imaging systems(170.4500) Optical coherence tomography(260.5430) Polarization

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Area of Science:

  • Biomedical Optics
  • Biophotonics
  • Medical Imaging

Background:

  • Birefringence is a crucial optical property of biological tissues.
  • Accurate measurement of birefringence is essential for understanding tissue structure and disease.
  • Current methods for birefringence measurement can be complex or limited in application.

Purpose of the Study:

  • To develop a simple and effective method for quantitative birefringence measurement.
  • To utilize an all single-mode fiber (SMF) based polarization-sensitive optical coherence tomography (PS-OCT) system.
  • To demonstrate the quantification of phase retardance and optic axis orientation in biological tissues.

Main Methods:

  • An all single-mode fiber (SMF) based polarization-sensitive optical coherence tomography (PS-OCT) system was employed.
  • A single input polarization state was used for the PS-OCT system.
  • A calibration process using a quarter wave plate (QWP) was performed to quantify phase retardance and optic axis orientation.

Main Results:

  • Theoretically verified the capability of the SMF-based PS-OCT system for birefringence quantification.
  • Successfully demonstrated the quantification of phase retardance and optic axis orientation.
  • Validated the method using a Berek polarization compensator and biological tissues.

Conclusions:

  • The proposed SMF-based PS-OCT method offers a simple yet effective approach for quantitative birefringence measurement.
  • This technique allows for accurate determination of phase retardance and optic axis orientation.
  • The demonstrated capability holds promise for various biomedical applications requiring tissue optical property analysis.