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Updated: Apr 7, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
Published on: February 18, 2015
Modulating gut immunity and neoplasia with oral cytokine adjuvants
Hatice Ozbilge1, Charles LeVea2, Allen Y Chung3
1Department of Pharmaceutical Microbiology; Erciyes University School of Medicine ; Kayseri, Turkey.
Abstract:
Oral administration of particulate IL-10 suppressed polyposis, ameliorated systemic pathology and extended lifespan in APCmin/+ mice. Therapeutic effect was associated with selective activity of IL-10 on intestinal CD4+Foxp3+RORγt+IL-17+ pathogenic T-regulatory cells. Studies were recently extended to a bacterially-driven murine colon adenocarcinoma model with similar results. Clinical implications of these findings are discussed.
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