Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

An Overview of the Endocrine System01:10

An Overview of the Endocrine System

19.2K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
19.2K
Autonomic Nervous System01:22

Autonomic Nervous System

16.1K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
16.1K
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

7.8K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
7.8K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

6.5K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
6.5K
Sympathetic Signaling01:31

Sympathetic Signaling

3.5K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
3.5K
Structures of the Endocrine System00:59

Structures of the Endocrine System

16.7K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
16.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.

American journal of physiology. Heart and circulatory physiology·2026
Same author

A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Activity dynamics in the NPY neuronal signaling of mPFC in response to an air puff.

Stress (Amsterdam, Netherlands)·2026
Same author

Guidelines for optimizing rigor and reproducibility in inclusion of premenopausal females in integrative physiology research.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

The intermediate conductance calcium-dependent K<sup>+</sup> channel does not contribute to the slow after hyperpolarization in oxytocin and vasopressin hypothalamic magnocellular neurons.

Journal of neuroendocrinology·2026
Same author

A Common Iba1 Antibody Labels Vasopressin Neurons in Mice.

eNeuro·2026
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiology·2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

16.2K

Endocrine-Autonomic Linkages.

Celia D Sladek1, Lisete C Michelini2, Nina S Stachenfeld3

  • 1Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, USA.

Comprehensive Physiology
|July 4, 2015
PubMed
Summary
This summary is machine-generated.

The autonomic and neuroendocrine systems interact to maintain homeostasis. This article explores how the hypothalamic paraventricular nucleus integrates these systems for essential physiological regulation, using exercise as a key example.

More Related Videos

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.4K
Homogeneous Time-resolved F&#246;rster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.9K

Related Experiment Videos

Last Updated: Apr 7, 2026

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions
10:24

Efficient Differentiation of Postganglionic Sympathetic Neurons using Human Pluripotent Stem Cells under Feeder-free and Chemically Defined Culture Conditions

Published on: May 24, 2020

16.2K
Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.4K
Homogeneous Time-resolved F&#246;rster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
07:30

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

Published on: May 10, 2018

9.9K

Area of Science:

  • Neuroendocrinology
  • Autonomic Nervous System Physiology
  • Homeostasis

Background:

  • The autonomic nervous system (ANS) and neuroendocrine system are crucial for maintaining physiological homeostasis.
  • Integration of these systems is vital for regulating body temperature, fluid balance, blood pressure, and volume.
  • The hypothalamic paraventricular nucleus (PVN) is a key integration center, containing both neuroendocrine and autonomic neurons.

Purpose of the Study:

  • To elucidate the anatomical and physiological mechanisms of neuroendocrine-autonomic system integration.
  • To describe communication pathways within the PVN between neuroendocrine and autonomic neuronal populations.
  • To discuss the influence of peripheral hormones and physiological challenges like exercise on this integrated response.

Main Methods:

  • Review of anatomical and physiological mechanisms underlying neuroendocrine-autonomic integration.
  • Focus on the hypothalamic paraventricular nucleus (PVN) as a central hub.
  • Discussion of 'wired' and 'nonwired' communication within the PVN.
  • Analysis of peripheral hormone (adrenal and gonadal steroids) impact.
  • Case study using exercise as a physiological stressor.

Main Results:

  • The PVN contains neuroendocrine and preganglionic autonomic neurons, facilitating integrated responses.
  • Specific 'wired' and 'nonwired' mechanisms enable communication between these neuronal types within the PVN.
  • Peripheral hormones significantly modulate neuroendocrine and autonomic functions.
  • Exercise necessitates precise integration of these systems for homeostasis.

Conclusions:

  • The hypothalamic paraventricular nucleus is a critical site for integrating autonomic and neuroendocrine functions.
  • Effective communication within the PVN and modulation by peripheral hormones are essential for maintaining homeostasis under physiological stress.
  • Understanding this integration is key to comprehending responses to challenges like exercise.