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Gabapentin in chronic cough.

Peter G Gibson1, Anne E Vertigan2

  • 1Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, NSW 2305, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.

Pulmonary Pharmacology & Therapeutics
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PubMed
Summary

Gabapentin offers a new treatment for chronic cough, reducing its frequency and severity. This neuromodulating medication improves quality of life for patients with refractory cough, particularly those with central reflex sensitization.

Keywords:
Chronic coughCough hypersensitivityGabapentinNeuropathic coughSpeech pathology

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Area of Science:

  • Neurology
  • Pulmonology
  • Pharmacology

Background:

  • Chronic cough presents a significant clinical challenge with limited treatment options.
  • Refractory chronic cough severely impairs patients' quality of life.

Purpose of the Study:

  • To review recent advancements in treating chronic cough, focusing on speech pathology and gabapentin.
  • To evaluate the effectiveness of neuromodulating medications for refractory chronic cough.

Main Methods:

  • Literature search of PubMed and SCOPUS for randomized controlled trials, reviews, and case reports from the last eight years.
  • Focus on speech pathology and pharmacotherapy with gabapentin.

Main Results:

  • Neuromodulating medications like gabapentin show effectiveness in reducing cough frequency and severity.
  • Gabapentin improves quality of life, with greatest effect in patients exhibiting central reflex sensitization.
  • Reported side effects of gabapentin include somnolence and dizziness.

Conclusions:

  • Chronic cough can be viewed as cough hypersensitivity, potentially with a neuropathic basis.
  • Speech pathology and gabapentin are effective treatments for refractory chronic cough targeting these mechanisms.