Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.2K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

3.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
3.2K
Autoimmune Disorders01:29

Autoimmune Disorders

2.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.2K
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

8.9K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.

Cell·2026
Same author

Transcriptomic rewiring of the JAK-STAT pathway in circulating CD4<sup>+</sup>CLA<sup>+</sup> and CD4<sup>+</sup> naïve T cells from patients with atopic dermatitis and psoriasis.

Frontiers in immunology·2026
Same author

Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota.

European journal of immunology·2026
Same author

AIRE's Complex Role Beyond Promiscuous Gene Expression.

Immunological reviews·2025
Same author

Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples.

European journal of immunology·2025
Same author

CD8⁺ T cell heterogeneity in aging: insights from single-cell profiling.

Immunity & ageing : I & A·2025
Same journal

Bronchiectasis in Inborn Errors of Immunity: Prevalence, Predictors, and Cardiopulmonary Complications in a Genetically Characterized Cohort.

Journal of clinical immunology·2026
Same journal

Adult-Onset LRBA Deficiency Presenting with Rheumatoid Arthritis-Like Manifestations: A Case Report.

Journal of clinical immunology·2026
Same journal

Immunopathological Profile of Patients with Thymic Epithelial Tumour and Good Syndrome in Advanced Stage.

Journal of clinical immunology·2026
Same journal

Facial Dysmorphism and Severe Vascular Phenotype in TRNT1 Deficiency with Concomitant Antithrombin III Deficiency.

Journal of clinical immunology·2026
Same journal

Intersection Between Systemic Autoimmune Diseases, Primary Immunodeficiency and Cancer: a Field in its Infancy.

Journal of clinical immunology·2026
Same journal

Disseminated Tuberculosis and Early-Onset SLE in a Child with a Novel STAT1 Gain-of-Function Mutation: a Case Report.

Journal of clinical immunology·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.

Kai Kisand1, Pärt Peterson

  • 1Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Str., Tartu, EE50411, Estonia, kai.kisand@ut.ee.

Journal of Clinical Immunology
|July 5, 2015
PubMed
Summary
This summary is machine-generated.

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare genetic disorder. This review details APECED

More Related Videos

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
12:08

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

9.8K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K

Related Experiment Videos

Last Updated: Apr 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.6K
Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
12:08

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

9.8K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K

Area of Science:

  • Immunology
  • Genetics
  • Endocrinology

Background:

  • Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disorder.
  • It results from mutations in the autoimmune regulator (AIRE) gene.

Purpose of the Study:

  • To review the clinical and immunological characteristics of APECED.
  • To summarize current knowledge on AIRE gene function.
  • To discuss the role of autoantibodies and recent immunomodulatory treatments.

Main Methods:

  • Literature review of APECED.
  • Analysis of AIRE gene function.
  • Evaluation of autoantibody significance.
  • Review of treatment outcomes.

Main Results:

  • APECED presents with a distinct set of clinical and immunological features.
  • AIRE gene mutations are the primary cause.
  • Autoantibodies are crucial for diagnosis and prognosis.
  • Immunomodulatory therapies show promising outcomes.

Conclusions:

  • Understanding APECED involves recognizing its genetic basis, clinical manifestations, and immunological underpinnings.
  • AIRE gene function is central to immune tolerance.
  • Autoantibodies serve as key biomarkers.
  • Emerging treatments offer new hope for patients.