Related Experiment Video
Updated: Apr 7, 2026
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.9K
Obstructive Sleep Apnea and Cardiovascular Disease - A New Target for Treatment
Giuseppe Schillaci, Francesca Battista, Giuseppe Fiorenzano
1Dipartimento di Medicina, Universita degli Studi di Perugia, Unita di Medicina Interna, Azienda Ospedaliero-Universitaria di Terni, piazzale Tristano di Joannuccio, 1, IT- 05100 Terni, Italy. giuseppe.schillaci@unipg.it.
Current Pharmaceutical Design
|July 7, 2015
Summary
Obstructive sleep apnea (OSA) increases cardiovascular risks like hypertension. Continuous positive airway pressure (CPAP) may lower blood pressure, but its effect on cardiovascular mortality requires further research.
Area of Science:
- Cardiology
- Pulmonology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) involves repeated breathing interruptions during sleep due to airway collapse.
- OSA is linked to significant cardiovascular issues, including hypertension, coronary artery disease, stroke, and heart failure.
Purpose of the Study:
- To assess the cardiovascular impact of OSA.
- To evaluate the potential benefits of continuous positive airway pressure (CPAP) on cardiovascular mortality.
Main Methods:
- Review of prospective studies on OSA and cardiovascular outcomes.
- Analysis of pathophysiological mechanisms linking OSA to cardiovascular changes.
- Examination of CPAP's effect on blood pressure in hypertensive patients.
Main Results:
- OSA is associated with increased risks of hypertension, coronary artery disease, stroke, and heart failure.
- CPAP treatment demonstrates a blood pressure-lowering effect, particularly in patients with high baseline pressure and good compliance.
- Current evidence does not support CPAP for primary or secondary cardiovascular disease prevention.
Conclusions:
- OSA poses substantial cardiovascular risks, especially hypertension.
- CPAP can mitigate hypertension in OSA patients.
- Further research is needed to clarify CPAP's role in preventing cardiovascular mortality.
More Related Videos
Related Concept Videos
01:21Sleep Apnea
784
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
784
01:26Atherosclerosis III: Management
592
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
592
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
4.6K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.6K
01:29Cardiomyopathy V: Interprofessional Care
670
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
670
01:26Coronary Artery Disease IV: Preventive Measures
861
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
861
01:26Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
654
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
654