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Updated: Apr 7, 2026

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Resistance Exercise Reduces Body Fat and Insulin During Androgen-Deprivation Therapy for Prostate Cancer
Kerri M Winters-Stone1, Nathan Dieckmann2, Gianni F Maddalozzo3
1School of Nursing, Oregon Health and Science University, Portland.
Purpose/Objectives:
To determine whether exercise could reduce biomarkers of cancer progression in prostate cancer survivors (PCSs) on androgen-deprivation therapy (ADT).
Design:
Randomized, controlled trial.
Setting:
Oregon Health and Science University School of Nursing.
Sample:
51 PCSs randomized to one year of resistance and impact training or a stretching control group.
Methods:
The authors investigated changes in body composition and cancer-related biomarkers, and the influence of age and fat loss on changes in biomarkers.
Main Research Variables:
Body composition (total fat, trunk fat, and lean mass), insulin, insulin-like growth factor-1, and sex hormone-binding globulin.
Findings:
In the 36 PCSs with baseline and 12-month data, total fat (p = 0.02) and trunk fat (p = 0.06) mass decreased in the training group compared to gains in controls. Loss of total and trunk fat each mediated the relationship between groups and one-year change in insulin (p < 0.05). Age moderated the insulin response to exercise where insulin reductions were smaller with increasing age (p = 0.03).
Conclusions:
Resistance and impact exercise may reduce body fat among PCSs undergoing ADT, in turn exerting an insulin-lowering effect.
Implications For Nursing:
Nurses should counsel PCSs to exercise to reduce the risk of obesity and associated conditions, including cancer progression.
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