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Updated: Apr 7, 2026

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
Published on: July 4, 2016
Strong and Selective Anion Binding within the Central Cavity of Molecular Knots and Links
Jean-François Ayme1, Jonathon E Beves1, Christopher J Campbell1
1School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Abstract:
A molecular pentafoil knot and doubly and triply entwined [2]catenanes based on circular Fe(II) double helicate scaffolds bind halide anions in their central cavities through electrostatic and CH···X(-) hydrogen-bonding interactions. The binding is up to (3.6 ± 0.2) × 10(10) M(-1) in acetonitrile (for pentafoil knot [2·Cl](PF6)9), making these topologically complex host molecules some of the strongest synthetic noncovalent binders of halide anions measured to date, comparable in chloride ion affinity to silver salts.
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