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Updated: Apr 7, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Nanometer-thick hyaluronic acid self-assemblies with strong adhesive properties
Andrew Marais1, Samuel Pendergraph1, Lars Wågberg1
1†Division of Fibre Technology, School of Chemical Science and Engineering, and §The Wallenberg Wood Science Centre, School of Chemical Science and Engineering, KTH Royal Institute of Technology, Stockholm, SE-100 44 Stockholm, Sweden.
Abstract:
The adhesive characteristics of poly(allylamine hydrochloride) (PAH)/hyaluronic acid (HA) self-assemblies were investigated using contact adhesion testing. Poly(dimethylsiloxane) spheres and silicon wafers were coated with layer-by-layer (LbL) assemblies of PAH/HA. No increase in adhesion was observed when surfaces covered with dried LbL films were placed in contact. However, bringing the coated surfaces in contact while wet and separating them after drying resulted in an increase by a factor of 100 in the work of adhesion (from one to three bilayers). Herein we discuss the adhesion in PAH/HA and PAH/poly(acrylic acid) assemblies. PAH/HA assemblies have potential application as strong biomedical adhesives.
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