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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Parallel reconstruction in accelerated multivoxel MR spectroscopy.

V O Boer1, D W J Klomp1, J Laterra2,3

  • 1Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Magnetic Resonance in Medicine
|July 8, 2015
PubMed
Summary
This summary is machine-generated.

Simultaneous acquisition of multiple voxels in magnetic resonance spectroscopy (MRS) is now possible, reducing scan times compared to single voxel (SV) methods. This technique uses sensitivity encoding to unfold signals from different locations.

Keywords:
MR spectroscopyhigh fieldmultibandmultivoxel

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Spectroscopy
  • Medical Physics

Background:

  • Conventional single voxel (SV) magnetic resonance spectroscopy (MRS) involves sequential acquisition, leading to longer scan times.
  • Sensitivity encoding (SENSE) is an established technique for accelerating MRI acquisition.
  • Developing faster MRS methods is crucial for clinical applications and research.

Purpose of the Study:

  • To develop and validate a method for simultaneous acquisition of multiple voxels in localized MRS.
  • To reduce total scan time by employing sensitivity encoding (SENSE) techniques.
  • To enable parallel acquisition of data from distinct anatomical regions.

Main Methods:

  • Utilized dual volume localization to excite voxels in both hemispheres concurrently.
  • Employed receiver coil sensitivity profiles to unfold the simultaneously acquired data.
  • Demonstrated the method at 3 Tesla (T) and 7T, measuring hippocampus and motor cortex regions.
  • Acquired spectra from a patient with a low-grade oligodendroglioma, comparing lesion and contralateral hemispheres.

Main Results:

  • Successfully generated and separated signals from two simultaneous voxels.
  • Spectral data closely matched conventional single voxel (SV) MRS acquisitions.
  • Observed an increased chemical shift displacement artifact, potentially addressable with advanced pulse designs.
  • Noted a noise increase (g-factor) during unfolding, which was more pronounced at 3T than 7T.

Conclusions:

  • Simultaneous multi-voxel MRS acquisition is feasible using modulated slice-selective pulses and SENSE.
  • The developed method offers a potential reduction in scan time for localized MRS.
  • Further optimization may mitigate artifacts and improve signal-to-noise ratio, especially at lower field strengths.