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Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy

Kevin Van der Jeught1, Sandra Van Lint1, Kris Thielemans1

  • 1Laboratory of Molecular and Cellular Therapy; Department of Biomedical Sciences; Vrije Universiteit Brussel ; Jette, Belgium.

Oncoimmunology
|July 9, 2015
PubMed

Keywords:
CD8+ T cellCTLs, cytotoxic T lymphocytesDCs, dendritic cellsFβ2, a fusokine consisting of IFNβ, fused to the ectodomain of the TGFβ receptor IIIFNβIMP, investigational medicinal productMDSCs, myeloid-derived suppressor cellsTAAs, tumor-associated antigensTGFβTME, tumor microenvironmentTiDCs, tumor-infiltrating DCscancerdendritic cellfusokineimmunotherapyintratumoralmRNAreceptor II

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