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Updated: Apr 7, 2026
Self-reporting Scaffolds for 3-Dimensional Cell Culture
Published on: November 7, 2013
Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH
Zeng-Ying Qiao1, Chun-Yuan Hou, Wen-Jing Zhao
1CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China. wanghao@nanoctr.cn wanglei@nanoctr.cn.
Abstract:
The bis(pyrene) conjugated pH-sensitive polymers () were synthesized and self-assembled into nanoparticles through hydrophobic interactions. The Nile red (NR) loaded nanoparticles showed red emission due to the FRET effect. The nanoparticles entered cells via endocytosis, and the microenvironmental pH in the endocytosis process was monitored in situ by the simultaneous dual-wavelength fluorescence changes.
