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[Analysis of recurrences of meningiomas following neurosurgical resection]
K Kajiwara1, H Fudaba, M Tsuha
1Department of Neurosurgery, Yamaguchi University.
Abstract:
A clinical and pathological study of 124 surgically treated patients with intracranial meningiomas was carried out to evaluate factors influencing recurrence. The patients ranged in age from 8 years to 75 years. Thirty-five (28.2%) were males and 89 (71.8%) were females. Recurrences occurred in 18 patients, once in eleven, twice in six, four times in one. The period from first surgery to recurrence ranged from 5 months to 84 months (mean 29.9 months). Age, sex, site of tumor, surgical grading, and histology were selected as analytic factors. Simpson's classification was used as surgical grading. All the patients with recurrences were younger than 60 years old, and particularly in the patients who were younger than 40 years the recurrence rate was high. Mean age of the group with recurrence was 41.8 years, which was significantly younger than that of the group without recurrence (52.0 years). In the group with recurrence, ten were males and eight were females. The recurrence rate was 28.6% in males, and was 9.0% in females. Thus the recurrence rate was significantly higher for males than for females (p = 0.016). It also seemed that the period from first surgery to recurrence was earlier for males than for females. The patients with meningiomas at posterior fossa or sphenoid ridge often had recurrences, and the recurrence rate was 29.4% and 21.7%, respectively. But these recurrence rates were not significantly higher than those at other sites. On the contrary, no recurrences occurred at convexity, intraventricle, and olfactory groove.(ABSTRACT TRUNCATED AT 250 WORDS)
Insights
Younger patients and males experienced higher rates of intracranial meningioma recurrence after surgery. Factors like age and sex significantly influence meningioma tumor regrowth, impacting long-term patient outcomes.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Context:
- Intracranial meningiomas are primary tumors of the central nervous system.
- Surgical resection is the primary treatment modality for meningiomas.
- Understanding recurrence patterns is crucial for improving patient management.
Purpose:
- To investigate clinical and pathological factors associated with intracranial meningioma recurrence.
- To identify patient demographics and tumor characteristics that predict higher recurrence rates.
Summary:
- A study of 124 surgically treated patients revealed recurrence in 18 cases.
- Younger patients (<40 years) and males showed significantly higher recurrence rates.
- Tumor location (posterior fossa, sphenoid ridge) showed a trend towards higher recurrence, though not statistically significant.
Impact:
- Identifies key risk factors for meningioma recurrence, including younger age and male sex.
- Informs surgical decision-making and the need for closer follow-up in high-risk individuals.
- Highlights the importance of considering patient demographics in predicting tumor behavior.